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Federica Buccino

Contatti
Telefono: 02.2399.8249
Skype: federicab333
E-mail: federica.buccino@polimi.it

Advanced Materials and Smart Structures

Relatore: Prof.ssa Laura Vergani

Tutor: Prof. Gaetano Cascini

Università di Provenienza: Politecnico di Milano - Ingegneria Biomedica

Titolo della Tesi: GAP - image-Guided computational and experimental Analysis of fractured Patients

GAP - image Guided computational and experimental Analysis of fractured Patients

Introduction

The dramatic increase in fragility fractures and the related health and economic burden rise the urge of a cutting-edge attitude to anticipate catastrophic fracture propagation in human bones.
Recent studies address the issue from a multi-scale perspective, elevating the micro-scale phenomena as the key for detecting early damage occurrence. However, several limitations arise specifically for defining a quantitative framework to assess the contribution of lacunar micro-pores to fracture initiation and propagation. Moreover, the need for high resolution imaging imposes time demanding post-processing phases.

In this context, GAP exploits synchrotron scans in combination with micro-mechanical tests, to offer a fracture mechanics-based approach for quantifying the critical stress intensification in healthy and diseased trabecular human bones. This is paired with a morphological and densitometric framework for capturing lacunar network differences in presence of pathological alterations To address the current time-consuming and computationally expensive manual/semi-automatic segmenting steps, we implement convolutional neural network to detect the initiation and propagation of micro-scale damages. The results highlight the intimate cross talks between toughening and weakening phenomena at micro-scale, paving the way for novel preventive strategies and patient-specific treatments.

Objectives

See Figure 2.

Methods

See Figure 2.

Results

  • Mapping local mechanical properties of human healthy and osteoporotic femoral heads (Fig. 3)
  • Clarifying the role of lacunae in damage initiation and progression (Fig. 4)
  • Localizing bone failure bands via validated numerical models (Fig. 5)